Symbol
Name
ID

Eif2ak3
eukaryotic translation initiation factor 2 alpha kinase 3
MGI:1341830

Phenotype annotations related to endocrine/exocrine glands

Darker colors indicate more annotations

Human Phenotypes	Diabetes mellitus	Insulin-resistant diabetes mellitus	Neonatal insulin-dependent diabetes mellitus	Type I diabetes mellitus	Reduced pancreatic beta cells	Exocrine pancreatic insufficiency	Hypothyroidism	Central hypothyroidism
Disease(s) Associated with EIF2AK3	Diabetes mellitus	Insulin-resistant diabetes mellitus	Neonatal insulin-dependent diabetes mellitus	Type I diabetes mellitus	Reduced pancreatic beta cells	Exocrine pancreatic insufficiency	Hypothyroidism	Central hypothyroidism
type 1 diabetes mellitus
Wolcott-Rallison syndrome

Mouse Phenotypes

abnormal exocrine pancreas morphology

abnormal pancreatic acinus morphology

abnormal pancreatic acinar cell morphology

exocrine pancreas atrophy

exocrine pancreatic insufficiency

abnormal pancreatic islet morphology

abnormal pancreatic alpha cell morphology

absent pancreatic alpha cells

increased pancreatic alpha cell number

decreased pancreatic beta cell number

absent pancreatic beta cells

small pancreatic islets

small pancreas

abnormal pancreatic beta cell physiology

abnormal insulin secretion

abnormal pancreas physiology

acute pancreas inflammation

Availability

Mouse Genotype

Eif2ak3^tm1Drc/Eif2ak3^tm1Drc

Eif2ak3^tm1Dron/Eif2ak3^tm1Dron

Eif2ak3^tm1.1Drc/Eif2ak3^tm1.1Drc
Tg(Ela1-cre)16Eps/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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